Lipid profile and thyroid hormone concentrations in children with epilepsy treated with oxcarbazepine monotherapy: a prospective long-term study
Background and purpose: To evaluate prospectively the changes and possible asso- ciations in lipid and thyroid profiles in children treated with oxcarbazepine (OXC) monotherapy. Methods: Serum total cholesterol (TC), high-density lipoprotein cholesterol (HDL- C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TGs), lipoprotein (a) [Lp(a)], free thyroxine (FT4), free triiodothyronine (FT3), thyrotropin (TSH) and gamma-glutamyltransferase (GGT) concentrations […]
Associations between obesity, adverse behavioral patterns and cardiovascular risk factors among adolescent inhabitants of a Greek island
Background: Excess weight, unhealthy lifestyle habits and their sequelae have become a well-recognized public health problem in most countries. The objective of the study was to examine the relationship of adolescent over- weight/obesity with behavioral habits and their associa- tion with blood pressure (BP) and lipid profile. Methods: Anthropometric parameters, lifestyle, BP and lipid profile […]
Comparing calculated LDL-C with directly measured LDL-C in healthy and in dyslipidemic children
Background: LDL-C is one of the strongest markers for atherosclerosis and therapeutic decisions in children are based on its levels. Friedewald formula (FF) which is usually used for the calculation of LDL-C (cLDL-C); and Anandaraja’s formula (AF) may under- or overestimate actual levels. Objective: To compare cLDL-C with directly measured LDL-C (dLDL-C) as a screening […]
Serum antibodies against Oxidized LDL in Children and Adolescents with and without Hypercholesterolemia
Background: The oxidative modification of LDL (oxLDL) appears to play a key role in the early developmental stages of atherosclerosis. Increased serum antibodies against the oxLDL (anti-oxLDL antibodies) have been found in adults with atherosclerotic diseases, as well as in healthy ones. However, the clinical significance and its precise role, atherogenic or atheroprotective, have not […]
Overview of the current status of familial hypercholesterolaemia care in over 60 countries – The EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)
Background and aims: Management of familial hypercholesterolaemia (FH) may vary across different settings due to factors related to population characteristics, practice, resources and/or policies. We conducted a survey among the worldwide network of EAS FHSC Lead Investigators to provide an overview of FH status in different countries. Methods: Lead Investigators from countries formally involved in […]
Effect of levetiracetam monotherapy on lipid profiles and thyroid hormones T in children with epilepsy: A prospective study
Achilleas Attilakos, Argirios Dinopoulos, Maria Tsirouda, Maria Paschalidou, Alexia Prasouli, Adiana Stamati, Nefeli Parasxou, Anastasia Garoufi Long-term treatment with some older antiepileptic drugs may lead to dyslipidemia or thyroid disturbances. The effect of levetiracetam (LEV), a newer broad spectrum antiepileptic agent, on cardiovascular risk factors is not yet sufficiently investigated. The purpose of this study […]
Thyroid dysfunction associated with increased low-density lipoprotein cholesterol in epileptic children treated with carbamazepine monotherapy: A causal relationship?
Achilleas Attilakos, Anastasia Garoufi, Konstantinos Voudris, Sotiria Mastroyianni, Aspasia Fotinou, Dimitrios T. Papadimitriou, Nikolaos Gavalakis, Alexia Prassouli, Eustathia Katsarou Objective: Lipid abnormalities and thyroid dysfunction have been reported in patients treated with antiepileptic drugs. The aim of this study was to evaluate prospectively the association between thyroid and lipid profile in children treated with carbamazepine […]