{"id":680,"date":"2020-08-01T15:38:03","date_gmt":"2020-08-01T15:38:03","guid":{"rendered":"http:\/\/garoufi.markware.gr\/?p=680"},"modified":"2020-08-01T15:38:03","modified_gmt":"2020-08-01T15:38:03","slug":"lipid-profile-and-thyroid-hormone-concentrations-in-children-with-epilepsy-treated-with-oxcarbazepine-monotherapy-a-prospective-long-term-study","status":"publish","type":"post","link":"https:\/\/garoufi.gr\/?p=680","title":{"rendered":"Lipid profile and thyroid hormone concentrations in children with epilepsy treated with oxcarbazepine monotherapy: a prospective long-term study"},"content":{"rendered":"<div class=\"page\" title=\"Page 1\">\n<div class=\"layoutArea\">\n<div class=\"column\">\n<p>Background and purpose: To evaluate prospectively the changes and possible asso- ciations in lipid and thyroid profiles in children treated with oxcarbazepine (OXC) monotherapy.<br \/>\nMethods: Serum total cholesterol (TC), high-density lipoprotein cholesterol (HDL- C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TGs), lipoprotein (a) [Lp(a)], free thyroxine (FT4), free triiodothyronine (FT3), thyrotropin (TSH) and gamma-glutamyltransferase (GGT) concentrations were measured in 23 children with epilepsy, before and at 8 and 18 months of OXC monotherapy.<\/p>\n<p>Results: Total cholesterol was significantly increased at 8 months (P = 0.033), whereas LDL-C was significantly increased at 8 and 18months (P&lt;0.001 and P = 0.004, respectively) of treatment. Lp(a) was significantly increased at 8 months (P = 0.042) and borderline significantly increased at 18 months (P = 0.050) of treat- ment. FT4 was significantly decreased at 8 and 18 months (P &lt; 0.001 and P = 0.002, respectively), and TSH levels were significantly increased at 8 and 18months (P = 0.002 and P = 0.001, respectively) of OXC monotherapy. GGT levels were sig- nificantly increased at 8 and 18 months (P &lt; 0.001) of treatment. There were no sig- nificant alterations in HDL-C, TGs and FT3 levels during the study. Significant positive correlations were found between GGT and LDL-C levels at 8 (r = 0.468, P = 0.024) and 18 months (r = 0.498, P = 0.016), and between TSH and TC at 18 months (r = 0.508, P = 0.013) of treatment.<\/p>\n<p>Conclusions: OXC monotherapy may cause significant and persistent alterations in lipid and thyroid profiles in children with epilepsy. The increase in LDL-C and TC levels may be associated with liver enzymes induction and thyroid dysfunction. Fur- ther long-term prospective studies are required to confirm these findings and to determine their clinical significance.<\/p>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Background and purpose: To evaluate prospectively the changes and possible asso- ciations in lipid and thyroid profiles in children treated with oxcarbazepine (OXC) monotherapy. Methods: Serum total cholesterol (TC), high-density lipoprotein cholesterol (HDL- C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TGs), lipoprotein (a) [Lp(a)], free thyroxine (FT4), free triiodothyronine (FT3), thyrotropin (TSH) and gamma-glutamyltransferase (GGT) concentrations [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-680","post","type-post","status-publish","format-standard","hentry","category-1"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Lipid profile and thyroid hormone concentrations in children with epilepsy treated with oxcarbazepine monotherapy: a prospective long-term study &#187; \u0393\u03b1\u03c1\u03bf\u03cd\u03c6\u03b7 A\u03bd\u03b1\u03c3\u03c4\u03b1\u03c3\u03af\u03b1<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/garoufi.gr\/?p=680\" \/>\n<meta property=\"og:locale\" content=\"el_GR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Lipid profile and thyroid hormone concentrations in children with epilepsy treated with oxcarbazepine monotherapy: a prospective long-term study &#187; \u0393\u03b1\u03c1\u03bf\u03cd\u03c6\u03b7 A\u03bd\u03b1\u03c3\u03c4\u03b1\u03c3\u03af\u03b1\" \/>\n<meta property=\"og:description\" content=\"Background and purpose: To evaluate prospectively the changes and possible asso- ciations in lipid and thyroid profiles in children treated with oxcarbazepine (OXC) monotherapy. Methods: Serum total cholesterol (TC), high-density lipoprotein cholesterol (HDL- C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TGs), lipoprotein (a) [Lp(a)], free thyroxine (FT4), free triiodothyronine (FT3), thyrotropin (TSH) and gamma-glutamyltransferase (GGT) concentrations [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/garoufi.gr\/?p=680\" \/>\n<meta property=\"og:site_name\" content=\"\u0393\u03b1\u03c1\u03bf\u03cd\u03c6\u03b7 A\u03bd\u03b1\u03c3\u03c4\u03b1\u03c3\u03af\u03b1\" \/>\n<meta property=\"article:published_time\" content=\"2020-08-01T15:38:03+00:00\" \/>\n<meta name=\"author\" content=\"wPIfqxr1Sa\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u03a3\u03c5\u03bd\u03c4\u03ac\u03c7\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc\" \/>\n\t<meta name=\"twitter:data1\" content=\"wPIfqxr1Sa\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u0395\u03ba\u03c4\u03b9\u03bc\u03ce\u03bc\u03b5\u03bd\u03bf\u03c2 \u03c7\u03c1\u03cc\u03bd\u03bf\u03c2 \u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 \u03bb\u03b5\u03c0\u03c4\u03cc\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/garoufi.gr\\\/?p=680#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/garoufi.gr\\\/?p=680\"},\"author\":{\"name\":\"wPIfqxr1Sa\",\"@id\":\"https:\\\/\\\/garoufi.gr\\\/#\\\/schema\\\/person\\\/47fe983bae497b5771ef0688ea8f8212\"},\"headline\":\"Lipid profile and thyroid hormone concentrations in children with epilepsy treated with oxcarbazepine monotherapy: a prospective long-term study\",\"datePublished\":\"2020-08-01T15:38:03+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/garoufi.gr\\\/?p=680\"},\"wordCount\":266,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/garoufi.gr\\\/#\\\/schema\\\/person\\\/5dc7fdeb96c29ba957bfc810803ad9e9\"},\"articleSection\":[\"\u0395\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd\u03c4\u03b1 \u03ac\u03c1\u03b8\u03c1\u03b1\"],\"inLanguage\":\"el\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/garoufi.gr\\\/?p=680#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/garoufi.gr\\\/?p=680\",\"url\":\"https:\\\/\\\/garoufi.gr\\\/?p=680\",\"name\":\"Lipid profile and thyroid hormone concentrations in children with epilepsy treated with oxcarbazepine monotherapy: a prospective long-term study &#187; \u0393\u03b1\u03c1\u03bf\u03cd\u03c6\u03b7 A\u03bd\u03b1\u03c3\u03c4\u03b1\u03c3\u03af\u03b1\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/garoufi.gr\\\/#website\"},\"datePublished\":\"2020-08-01T15:38:03+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/garoufi.gr\\\/?p=680#breadcrumb\"},\"inLanguage\":\"el\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/garoufi.gr\\\/?p=680\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/garoufi.gr\\\/?p=680#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/garoufi.gr\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u0394\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03c5\u03c3\u03b5\u03b9\u03c2\",\"item\":\"https:\\\/\\\/garoufi.gr\\\/?cat=3\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"\u0395\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd\u03c4\u03b1 \u03ac\u03c1\u03b8\u03c1\u03b1\",\"item\":\"https:\\\/\\\/garoufi.gr\\\/?cat=1\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Lipid profile and thyroid hormone concentrations in children with epilepsy treated with oxcarbazepine monotherapy: a prospective long-term study\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/garoufi.gr\\\/#website\",\"url\":\"https:\\\/\\\/garoufi.gr\\\/\",\"name\":\"\u0393\u03b1\u03c1\u03bf\u03cd\u03c6\u03b7 A\u03bd\u03b1\u03c3\u03c4\u03b1\u03c3\u03af\u03b1\",\"description\":\"\u0399\u03b1\u03c4\u03c1\u03b5\u03af\u03bf \u0394\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ce\u03bd \u03c4\u03c9\u03bd \u039b\u03b9\u03c0\u03b9\u03b4\u03af\u03c9\u03bd\",\"publisher\":{\"@id\":\"https:\\\/\\\/garoufi.gr\\\/#\\\/schema\\\/person\\\/5dc7fdeb96c29ba957bfc810803ad9e9\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/garoufi.gr\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"el\"},{\"@type\":[\"Person\",\"Organization\"],\"@id\":\"https:\\\/\\\/garoufi.gr\\\/#\\\/schema\\\/person\\\/5dc7fdeb96c29ba957bfc810803ad9e9\",\"name\":\"Garoufi\",\"logo\":{\"@id\":\"https:\\\/\\\/garoufi.gr\\\/#\\\/schema\\\/person\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/garoufi.gr\\\/#\\\/schema\\\/person\\\/47fe983bae497b5771ef0688ea8f8212\",\"name\":\"wPIfqxr1Sa\",\"sameAs\":[\"http:\\\/\\\/garoufi.markware.gr\"],\"url\":\"https:\\\/\\\/garoufi.gr\\\/?author=1\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Lipid profile and thyroid hormone concentrations in children with epilepsy treated with oxcarbazepine monotherapy: a prospective long-term study &#187; \u0393\u03b1\u03c1\u03bf\u03cd\u03c6\u03b7 A\u03bd\u03b1\u03c3\u03c4\u03b1\u03c3\u03af\u03b1","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/garoufi.gr\/?p=680","og_locale":"el_GR","og_type":"article","og_title":"Lipid profile and thyroid hormone concentrations in children with epilepsy treated with oxcarbazepine monotherapy: a prospective long-term study &#187; \u0393\u03b1\u03c1\u03bf\u03cd\u03c6\u03b7 A\u03bd\u03b1\u03c3\u03c4\u03b1\u03c3\u03af\u03b1","og_description":"Background and purpose: To evaluate prospectively the changes and possible asso- ciations in lipid and thyroid profiles in children treated with oxcarbazepine (OXC) monotherapy. Methods: Serum total cholesterol (TC), high-density lipoprotein cholesterol (HDL- C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TGs), lipoprotein (a) [Lp(a)], free thyroxine (FT4), free triiodothyronine (FT3), thyrotropin (TSH) and gamma-glutamyltransferase (GGT) concentrations [&hellip;]","og_url":"https:\/\/garoufi.gr\/?p=680","og_site_name":"\u0393\u03b1\u03c1\u03bf\u03cd\u03c6\u03b7 A\u03bd\u03b1\u03c3\u03c4\u03b1\u03c3\u03af\u03b1","article_published_time":"2020-08-01T15:38:03+00:00","author":"wPIfqxr1Sa","twitter_card":"summary_large_image","twitter_misc":{"\u03a3\u03c5\u03bd\u03c4\u03ac\u03c7\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc":"wPIfqxr1Sa","\u0395\u03ba\u03c4\u03b9\u03bc\u03ce\u03bc\u03b5\u03bd\u03bf\u03c2 \u03c7\u03c1\u03cc\u03bd\u03bf\u03c2 \u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2":"1 \u03bb\u03b5\u03c0\u03c4\u03cc"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/garoufi.gr\/?p=680#article","isPartOf":{"@id":"https:\/\/garoufi.gr\/?p=680"},"author":{"name":"wPIfqxr1Sa","@id":"https:\/\/garoufi.gr\/#\/schema\/person\/47fe983bae497b5771ef0688ea8f8212"},"headline":"Lipid profile and thyroid hormone concentrations in children with epilepsy treated with oxcarbazepine monotherapy: a prospective long-term study","datePublished":"2020-08-01T15:38:03+00:00","mainEntityOfPage":{"@id":"https:\/\/garoufi.gr\/?p=680"},"wordCount":266,"commentCount":0,"publisher":{"@id":"https:\/\/garoufi.gr\/#\/schema\/person\/5dc7fdeb96c29ba957bfc810803ad9e9"},"articleSection":["\u0395\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd\u03c4\u03b1 \u03ac\u03c1\u03b8\u03c1\u03b1"],"inLanguage":"el","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/garoufi.gr\/?p=680#respond"]}]},{"@type":"WebPage","@id":"https:\/\/garoufi.gr\/?p=680","url":"https:\/\/garoufi.gr\/?p=680","name":"Lipid profile and thyroid hormone concentrations in children with epilepsy treated with oxcarbazepine monotherapy: a prospective long-term study &#187; \u0393\u03b1\u03c1\u03bf\u03cd\u03c6\u03b7 A\u03bd\u03b1\u03c3\u03c4\u03b1\u03c3\u03af\u03b1","isPartOf":{"@id":"https:\/\/garoufi.gr\/#website"},"datePublished":"2020-08-01T15:38:03+00:00","breadcrumb":{"@id":"https:\/\/garoufi.gr\/?p=680#breadcrumb"},"inLanguage":"el","potentialAction":[{"@type":"ReadAction","target":["https:\/\/garoufi.gr\/?p=680"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/garoufi.gr\/?p=680#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/garoufi.gr\/"},{"@type":"ListItem","position":2,"name":"\u0394\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03c5\u03c3\u03b5\u03b9\u03c2","item":"https:\/\/garoufi.gr\/?cat=3"},{"@type":"ListItem","position":3,"name":"\u0395\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd\u03c4\u03b1 \u03ac\u03c1\u03b8\u03c1\u03b1","item":"https:\/\/garoufi.gr\/?cat=1"},{"@type":"ListItem","position":4,"name":"Lipid profile and thyroid hormone concentrations in children with epilepsy treated with oxcarbazepine monotherapy: a prospective long-term study"}]},{"@type":"WebSite","@id":"https:\/\/garoufi.gr\/#website","url":"https:\/\/garoufi.gr\/","name":"\u0393\u03b1\u03c1\u03bf\u03cd\u03c6\u03b7 A\u03bd\u03b1\u03c3\u03c4\u03b1\u03c3\u03af\u03b1","description":"\u0399\u03b1\u03c4\u03c1\u03b5\u03af\u03bf \u0394\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ce\u03bd \u03c4\u03c9\u03bd \u039b\u03b9\u03c0\u03b9\u03b4\u03af\u03c9\u03bd","publisher":{"@id":"https:\/\/garoufi.gr\/#\/schema\/person\/5dc7fdeb96c29ba957bfc810803ad9e9"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/garoufi.gr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"el"},{"@type":["Person","Organization"],"@id":"https:\/\/garoufi.gr\/#\/schema\/person\/5dc7fdeb96c29ba957bfc810803ad9e9","name":"Garoufi","logo":{"@id":"https:\/\/garoufi.gr\/#\/schema\/person\/image\/"}},{"@type":"Person","@id":"https:\/\/garoufi.gr\/#\/schema\/person\/47fe983bae497b5771ef0688ea8f8212","name":"wPIfqxr1Sa","sameAs":["http:\/\/garoufi.markware.gr"],"url":"https:\/\/garoufi.gr\/?author=1"}]}},"_links":{"self":[{"href":"https:\/\/garoufi.gr\/index.php?rest_route=\/wp\/v2\/posts\/680","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/garoufi.gr\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/garoufi.gr\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/garoufi.gr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/garoufi.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=680"}],"version-history":[{"count":1,"href":"https:\/\/garoufi.gr\/index.php?rest_route=\/wp\/v2\/posts\/680\/revisions"}],"predecessor-version":[{"id":681,"href":"https:\/\/garoufi.gr\/index.php?rest_route=\/wp\/v2\/posts\/680\/revisions\/681"}],"wp:attachment":[{"href":"https:\/\/garoufi.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=680"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/garoufi.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=680"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/garoufi.gr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=680"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}