{"id":661,"date":"2020-08-01T15:06:47","date_gmt":"2020-08-01T15:06:47","guid":{"rendered":"http:\/\/garoufi.markware.gr\/?p=661"},"modified":"2020-08-01T15:08:54","modified_gmt":"2020-08-01T15:08:54","slug":"thyroid-dysfunction-associated-with-increased-low-density-lipoprotein-cholesterol-in-epileptic-children-treated-with-carbamazepine-monotherapy-a-causal-relationship","status":"publish","type":"post","link":"https:\/\/garoufi.gr\/?p=661","title":{"rendered":"Thyroid dysfunction associated with increased low-density lipoprotein cholesterol in epileptic children treated with carbamazepine monotherapy: A causal relationship?"},"content":{"rendered":"
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Achilleas Attilakos, Anastasia Garoufi, Konstantinos Voudris, Sotiria Mastroyianni, Aspasia Fotinou, Dimitrios T. Papadimitriou, Nikolaos Gavalakis, Alexia Prassouli, Eustathia Katsarou<\/em><\/p>\n<\/div>\n

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Objective: Lipid abnormalities and thyroid dysfunction have been reported in patients treated with antiepileptic drugs. The aim of this study was to evaluate prospectively the association between thyroid and lipid profile in children treated with carbamazepine (CBZ) monotherapy.<\/p>\n

Materials and methods: Thyroid function was evaluated in 18 epileptic children, previously reported with CBZ-induced changes in serum lipid profile, before and at 6, 12 and 24 months of CBZ monotherapy.
\nResults: All children had normal thyroid function before the initiation of CBZ treatment. During CBZ therapy thyroid dysfunction, with increased thyrotropin (TSH) and decreased thyroxine (T4), free thyroxine (FT4) and triiodothyronine (T3) was found, while, significant association was revealed between serum low-density lipoprotein cholesterol (LDL-C) and TSH levels at 6 (r 1\u20444 0.469; p 1\u20444 0.043) and 12 (r 1\u20444 0.730; p 1\u20444 0.001) months of treatment. Conclusion: Lipid abnormalities may be associated with thyroid hormone disturbance in children treated with CBZ monotherapy. Since thyroid dysfunction and hypercholester- olemia are both associated with a higher atherosclerotic risk special attention and further studies are needed in epileptic patients treated with CBZ monotherapy.<\/p>\n

& 2007 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

Attilakos et al-TSH-LDL-Carbamazepine-Eur J Ped Neurol 2007<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Achilleas Attilakos, Anastasia Garoufi, Konstantinos Voudris, Sotiria Mastroyianni, Aspasia Fotinou, Dimitrios T. Papadimitriou, Nikolaos Gavalakis, Alexia Prassouli, Eustathia Katsarou Objective: Lipid abnormalities and thyroid dysfunction have been reported in patients treated with antiepileptic drugs. The aim of this study was to evaluate prospectively the association between thyroid and lipid profile in children treated with carbamazepine […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-661","post","type-post","status-publish","format-standard","hentry","category-3"],"yoast_head":"\nThyroid dysfunction associated with increased low-density lipoprotein cholesterol in epileptic children treated with carbamazepine monotherapy: A causal relationship? » \u0393\u03b1\u03c1\u03bf\u03cd\u03c6\u03b7 A\u03bd\u03b1\u03c3\u03c4\u03b1\u03c3\u03af\u03b1<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/garoufi.gr\/?p=661\" \/>\n<meta property=\"og:locale\" content=\"el_GR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Thyroid dysfunction associated with increased low-density lipoprotein cholesterol in epileptic children treated with carbamazepine monotherapy: A causal relationship? » \u0393\u03b1\u03c1\u03bf\u03cd\u03c6\u03b7 A\u03bd\u03b1\u03c3\u03c4\u03b1\u03c3\u03af\u03b1\" \/>\n<meta property=\"og:description\" content=\"Achilleas Attilakos, Anastasia Garoufi, Konstantinos Voudris, Sotiria Mastroyianni, Aspasia Fotinou, Dimitrios T. Papadimitriou, Nikolaos Gavalakis, Alexia Prassouli, Eustathia Katsarou Objective: Lipid abnormalities and thyroid dysfunction have been reported in patients treated with antiepileptic drugs. The aim of this study was to evaluate prospectively the association between thyroid and lipid profile in children treated with carbamazepine […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/garoufi.gr\/?p=661\" \/>\n<meta property=\"og:site_name\" content=\"\u0393\u03b1\u03c1\u03bf\u03cd\u03c6\u03b7 A\u03bd\u03b1\u03c3\u03c4\u03b1\u03c3\u03af\u03b1\" \/>\n<meta property=\"article:published_time\" content=\"2020-08-01T15:06:47+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-08-01T15:08:54+00:00\" \/>\n<meta name=\"author\" content=\"wPIfqxr1Sa\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u03a3\u03c5\u03bd\u03c4\u03ac\u03c7\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc\" \/>\n\t<meta name=\"twitter:data1\" content=\"wPIfqxr1Sa\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u0395\u03ba\u03c4\u03b9\u03bc\u03ce\u03bc\u03b5\u03bd\u03bf\u03c2 \u03c7\u03c1\u03cc\u03bd\u03bf\u03c2 \u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 \u03bb\u03b5\u03c0\u03c4\u03cc\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/garoufi.gr\\\/?p=661#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/garoufi.gr\\\/?p=661\"},\"author\":{\"name\":\"wPIfqxr1Sa\",\"@id\":\"https:\\\/\\\/garoufi.gr\\\/#\\\/schema\\\/person\\\/47fe983bae497b5771ef0688ea8f8212\"},\"headline\":\"Thyroid dysfunction associated with increased low-density lipoprotein cholesterol in epileptic children treated with carbamazepine monotherapy: A causal relationship?\",\"datePublished\":\"2020-08-01T15:06:47+00:00\",\"dateModified\":\"2020-08-01T15:08:54+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/garoufi.gr\\\/?p=661\"},\"wordCount\":221,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/garoufi.gr\\\/#\\\/schema\\\/person\\\/5dc7fdeb96c29ba957bfc810803ad9e9\"},\"articleSection\":[\"\u0394\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03c5\u03c3\u03b5\u03b9\u03c2\"],\"inLanguage\":\"el\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/garoufi.gr\\\/?p=661#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/garoufi.gr\\\/?p=661\",\"url\":\"https:\\\/\\\/garoufi.gr\\\/?p=661\",\"name\":\"Thyroid dysfunction associated with increased low-density lipoprotein cholesterol in epileptic children treated with carbamazepine monotherapy: A causal relationship? 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